Target Analysis of Serum-Extract using MS/MS Mode (MRM and subsequent
Product Ion Scan for different Compounds, including e.g. Morphine and Zopiclon).

Fig. 1: Upper panel: TIC; three panels (2nd to bottom) resulting in three +MS2 spectra at 20, 35 and 50 eV CE

Identification by Library Search (50 eV MS/MS spectrum)

Yielding good fit values (0.974 for fit, 0.974 for reverse fit, 0.973 for purity fit).

Applications:

 a) Compound Identification after Screening with LC-in-sourceCID-MS

 b) Multi Target-Screening Analysis (MRM mode) with subsequent MS/MS and identification by library search

                        (Gergov M, Ojanperä I, Vuori E: J Chrom B, 795 (2003) 41-53)

c)           MULTI TARGET SCREENING (MTS) FOR 300 DRUGS USING A LINEAR ION TRAP

              MASS SPECTROMETER AND LIBRARY SEARCHING
              (presented at SOFT/TIAFT Washington 2004)

d) General Unknown-Screening with LINEAR ION TRAP with in-source CID and IDA/Library Searching